Clarithromycin in adult-onset Still’s disease: a study of 6 cases
Identifieur interne : 001891 ( Main/Exploration ); précédent : 001890; suivant : 001892Clarithromycin in adult-onset Still’s disease: a study of 6 cases
Auteurs : Gianantonio Saviola [Italie] ; Maurizio Benucci [Italie] ; Lul Abdi-Ali [Italie] ; Paola Baiardi [Italie] ; Mariangela Manfredi [Italie] ; Mariarosaria Bucci [Italie] ; Giuseppe Cirino [Italie]Source :
- Rheumatology International [ 0172-8172 ] ; 2010-02-01.
English descriptors
Abstract
Abstract: Adult-onset Still’s disease (AOSD) is a rare rheumatological condition characterized by an acute systemic involvement. There are no treatment guidelines. Glucocorticoids (GC), methotrexate (MTX), cyclosporin A and biologic agents have been successfully used, often in association. We treated six cases of AOSD with clarithromycin (CM) in combination with low-mild dose of GC and MTX. Four of them were not responsive to high-dose GC added to DMARDs, while two of them were treated with low-mild dose of GC added to CM from the beginning. CM, 500 mg b.i.d., was added to a mild-low dose of GC and to MTX. The dose of the drugs was reduced (and stopped where possible) following clinical and laboratory parameters. ACR criteria were used to assess clinical improvement. At 6 months 5 patients reached ACR 70% and could stop any therapy in 6–18 months; 1 continued chronic therapy with low-dose GC added to CM and MTX to maintain ACR 50%. CM can be a useful drug for the treatment of AOSD, even in patients not responsive to high-dose GC and DMARDs. No definitive conclusion can be drawn based on the present study.
Url:
DOI: 10.1007/s00296-009-1277-9
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000698
- to stream Istex, to step Curation: 000698
- to stream Istex, to step Checkpoint: 000816
- to stream Main, to step Merge: 001895
- to stream Main, to step Curation: 001891
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clarithromycin in adult-onset Still’s disease: a study of 6 cases</title><author><name sortKey="Saviola, Gianantonio" sort="Saviola, Gianantonio" uniqKey="Saviola G" first="Gianantonio" last="Saviola">Gianantonio Saviola</name></author><author><name sortKey="Benucci, Maurizio" sort="Benucci, Maurizio" uniqKey="Benucci M" first="Maurizio" last="Benucci">Maurizio Benucci</name></author><author><name sortKey="Abdi Ali, Lul" sort="Abdi Ali, Lul" uniqKey="Abdi Ali L" first="Lul" last="Abdi-Ali">Lul Abdi-Ali</name></author><author><name sortKey="Baiardi, Paola" sort="Baiardi, Paola" uniqKey="Baiardi P" first="Paola" last="Baiardi">Paola Baiardi</name></author><author><name sortKey="Manfredi, Mariangela" sort="Manfredi, Mariangela" uniqKey="Manfredi M" first="Mariangela" last="Manfredi">Mariangela Manfredi</name></author><author><name sortKey="Bucci, Mariarosaria" sort="Bucci, Mariarosaria" uniqKey="Bucci M" first="Mariarosaria" last="Bucci">Mariarosaria Bucci</name></author><author><name sortKey="Cirino, Giuseppe" sort="Cirino, Giuseppe" uniqKey="Cirino G" first="Giuseppe" last="Cirino">Giuseppe Cirino</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:621A5EC824C6A3489ACA8407CF9619E75C2B6F5B</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1007/s00296-009-1277-9</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-PHKJRK4G-9/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000698</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000698</idno><idno type="wicri:Area/Istex/Curation">000698</idno><idno type="wicri:Area/Istex/Checkpoint">000816</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000816</idno><idno type="wicri:doubleKey">0172-8172:2009:Saviola G:clarithromycin:in:adult</idno><idno type="wicri:Area/Main/Merge">001895</idno><idno type="wicri:Area/Main/Curation">001891</idno><idno type="wicri:Area/Main/Exploration">001891</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Clarithromycin in adult-onset Still’s disease: a study of 6 cases</title><author><name sortKey="Saviola, Gianantonio" sort="Saviola, Gianantonio" uniqKey="Saviola G" first="Gianantonio" last="Saviola">Gianantonio Saviola</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Rheumatology and Rehabilitation Unit, Salvatore Maugeri Foundation IRCCS, 46042, Castel Goffredo, Mantua</wicri:regionArea><wicri:noRegion>Mantua</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Italie</country></affiliation></author><author><name sortKey="Benucci, Maurizio" sort="Benucci, Maurizio" uniqKey="Benucci M" first="Maurizio" last="Benucci">Maurizio Benucci</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Rheumatology Unit, New Hospital S. Giovanni di Dio, ASL 10, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Abdi Ali, Lul" sort="Abdi Ali, Lul" uniqKey="Abdi Ali L" first="Lul" last="Abdi-Ali">Lul Abdi-Ali</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Rheumatology and Rehabilitation Unit, Salvatore Maugeri Foundation IRCCS, 46042, Castel Goffredo, Mantua</wicri:regionArea><wicri:noRegion>Mantua</wicri:noRegion></affiliation></author><author><name sortKey="Baiardi, Paola" sort="Baiardi, Paola" uniqKey="Baiardi P" first="Paola" last="Baiardi">Paola Baiardi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Methodology Unit, Consorzio Valutazioni Biologiche e Farmacologiche, Salvatore Maugeri Foundation IRCCS and University of Pavia, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Manfredi, Mariangela" sort="Manfredi, Mariangela" uniqKey="Manfredi M" first="Mariangela" last="Manfredi">Mariangela Manfredi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Immunology and Allergology Laboratory Unit, New Hospital S. Giovanni di Dio, ASL 10, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Bucci, Mariarosaria" sort="Bucci, Mariarosaria" uniqKey="Bucci M" first="Mariarosaria" last="Bucci">Mariarosaria Bucci</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples–Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Cirino, Giuseppe" sort="Cirino, Giuseppe" uniqKey="Cirino G" first="Giuseppe" last="Cirino">Giuseppe Cirino</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples–Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Rheumatology International</title><title level="j" type="sub">Clinical and Experimental Investigations</title><title level="j" type="abbrev">Rheumatol Int</title><idno type="ISSN">0172-8172</idno><idno type="eISSN">1437-160X</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="2010-02-01">2010-02-01</date><biblScope unit="volume">30</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="555">555</biblScope><biblScope unit="page" to="560">560</biblScope></imprint><idno type="ISSN">0172-8172</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0172-8172</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AOSD</term><term>Adult-onset Still’s disease</term><term>Clarithromycin</term><term>Macrolide antibiotics</term><term>Rheumatic disease</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Adult-onset Still’s disease (AOSD) is a rare rheumatological condition characterized by an acute systemic involvement. There are no treatment guidelines. Glucocorticoids (GC), methotrexate (MTX), cyclosporin A and biologic agents have been successfully used, often in association. We treated six cases of AOSD with clarithromycin (CM) in combination with low-mild dose of GC and MTX. Four of them were not responsive to high-dose GC added to DMARDs, while two of them were treated with low-mild dose of GC added to CM from the beginning. CM, 500 mg b.i.d., was added to a mild-low dose of GC and to MTX. The dose of the drugs was reduced (and stopped where possible) following clinical and laboratory parameters. ACR criteria were used to assess clinical improvement. At 6 months 5 patients reached ACR 70% and could stop any therapy in 6–18 months; 1 continued chronic therapy with low-dose GC added to CM and MTX to maintain ACR 50%. CM can be a useful drug for the treatment of AOSD, even in patients not responsive to high-dose GC and DMARDs. No definitive conclusion can be drawn based on the present study.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Saviola, Gianantonio" sort="Saviola, Gianantonio" uniqKey="Saviola G" first="Gianantonio" last="Saviola">Gianantonio Saviola</name></noRegion><name sortKey="Abdi Ali, Lul" sort="Abdi Ali, Lul" uniqKey="Abdi Ali L" first="Lul" last="Abdi-Ali">Lul Abdi-Ali</name><name sortKey="Baiardi, Paola" sort="Baiardi, Paola" uniqKey="Baiardi P" first="Paola" last="Baiardi">Paola Baiardi</name><name sortKey="Benucci, Maurizio" sort="Benucci, Maurizio" uniqKey="Benucci M" first="Maurizio" last="Benucci">Maurizio Benucci</name><name sortKey="Bucci, Mariarosaria" sort="Bucci, Mariarosaria" uniqKey="Bucci M" first="Mariarosaria" last="Bucci">Mariarosaria Bucci</name><name sortKey="Cirino, Giuseppe" sort="Cirino, Giuseppe" uniqKey="Cirino G" first="Giuseppe" last="Cirino">Giuseppe Cirino</name><name sortKey="Manfredi, Mariangela" sort="Manfredi, Mariangela" uniqKey="Manfredi M" first="Mariangela" last="Manfredi">Mariangela Manfredi</name><name sortKey="Saviola, Gianantonio" sort="Saviola, Gianantonio" uniqKey="Saviola G" first="Gianantonio" last="Saviola">Gianantonio Saviola</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001891 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001891 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:621A5EC824C6A3489ACA8407CF9619E75C2B6F5B
|texte= Clarithromycin in adult-onset Still’s disease: a study of 6 cases
}}
| This area was generated with Dilib version V0.6.33. |  |